Tissue regeneration technology developer Orthocell’s CellGro collagen tissue regeneration scaffolds may be useful in treating the limb swelling caused by lymphedema, a condition for which there is no known cure.
The company announced research published in proceedings of the National Academy of Sciences of the United States (PNAS) which suggests that combining CelGro with lymphatic and blood vessel cells could be used to create functional lymphatic tissue.
The research was a collaboration between Professor Shulamit Levenberg at the Technion – Israel Institute of Technology and Orthocell’s Professor Minghao Zheng at the Perron Institute and the University of Western Australia.
The company, which has been developing CelGro for use as dental scaffolds, to repair severed peripheral nerves, and for bone and tissue regeneration, also announced it had advanced the fabrication of implantable lymphatic grafts which had implications for the surgical treatment of lymphedema.
Professor Zheng, Orthocell’s chief scientific officer said: “Lymphedema is a common and debilitating complication of breast cancer treatments with suboptimal patient outcomes.
“This study provides a new understanding of the tole of CelGro in fabrication of tissue grafts for lymphatic vessel regeneration, which could have significant implications.”
Orthocell’s CelGro is bio-compatible, bio-absorbable and mechanically strong, allowing for multiple uses either on its own or in combination with autologous cells or growth factors.
The PNAS study may be viewed here.
Picture: Orthocell/70mm CelGro scaffold
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